Event planner Robert Isabell had four tons of glitter dumped in a four-inch layer on the floor of Studio 54 for a New Year's Eve party, which owner Ian Schrager described as like "standing on stardust" and left glitter that could be found months later in their clothing and homes. Frequent regulars at Studio 54 included Andy Warhol, Liza Minnelli, Bianca Jagger, Elizabeth Taylor, Halston, Mick Jagger, Jerry Hall, Debbie Harry, Grace Jones, Michael Jackson, Calvin Klein, Elton John, Tina Turner, Divine, Margaret Trudeau, Sylvia Miles, Francesco Scavullo, Truman Capote, Margaux Hemingway, Janice Dickinson, Mikhail Baryshnikov, Diana Ross, Cher, Salvador Dali, Diana Vreeland, John Travolta, Jackie Kennedy Onassis, Brooke Shields and Martha Graham.
Performers at Studio 54 during its first few years of operation included Grace Jones, Donna Summer, Stevie Wonder, James Brown, Gloria Gaynor, Sylvester, Amii Stewart, Stephanie Mills, The Ritchie Family, The Village People, Anita Ward, Two Tons o' Fun, Jocelyn Brown, France Joli, Cheryl Lynn, Jean Carne, Claudja Barry, Klaus Nomi and Linda Clifford.